MMC100新陈代谢笼用于小鼠的实验，是一个独立的单元，设计用于单个小鼠的长达24小时的实验。该代谢笼具有独特的功能，可以最大程度的减少尿液收集的污染。

MMC100新陈代谢笼由不锈钢和丙烯酸制成，有以下的8个组件：
1  顶部圆筒
2  底部圆筒 
3  底板
4  收集漏斗
5  盖子
6  喂食器

收集步骤:
新陈代谢笼的高效收集的关键在于收集漏斗。它收集小鼠的尿液小滴，使之慢慢的聚集到中间的球状物上，直到足够多后就会滴落到下面的收集容器中。任何的杂质，即使没有被底板排除在外，也会被漏斗排除在外，使杂质不会进入到收集容器中,得到完整、清洁的样品。

肥胖设计:
肥胖的设计和标准的代谢笼有一个区别：在顶部的圆筒上的臂是45˚角的，以便于安装超重小鼠的喂食和喂水器。肥胖的设计包括先前提到的标准设计相同的功能。此外，虽然最初是为肥胖小鼠设计的，但是这个笼子也可以适用于标准的小鼠。

冷却系统设计:
冷却系统分为两部分，包括绝缘笼基座和连接到冷却系统的基座插头。 这个笼子提供了一个方便的方法去保持整个收集过程中的样品温度在或低于45˚F（7˚C）。

1    易于使用、安装和清洁
2    精确的从粪便中分离尿液
3    很少的组成结构和耗材
4    由坚固耐用的丙烯酸材料制作
5    不锈钢材料的底板和收集漏斗  
6    O形环密封圈用于刚性连接    
7    透明设计，便于观察  
8    提供24小时、2-5ml的收集 
9    尿液收集容器是可移动的
10  符合实验动物使用和护理的要求 
11  可选的肥胖和冷却系统设计

1    易于使用、安装和清洁
2    精确的从粪便中分离尿液
3    很少的组成结构和耗材
4    由坚固耐用的丙烯酸材料制作
5    不锈钢材料的底板和收集漏斗 
6    O形环密封圈用于刚性连接
7    透明设计，便于观察 
8    提供24小时、2-5ml的收集
9    尿液收集容器是可移动的
10  符合实验动物使用和护理的要求
11  可选的肥胖和冷却系统设计

新陈代谢笼可用于多种研究，包括（但不仅仅限于）：
1 药物治疗的效果  
2 肾功能的研究
3 尿蛋白排泄
4 每日摄入的食物和水
5 表型
6 评价标准或干预的代谢功能
7 尿排泄量
该代谢笼也可以改良成用于肥胖小鼠，或者/和包含一个绝缘的基座以链接CCS2000冷却系统。

KynurenineInfusion Disrupts Normal Blood Pressure Circadian Rhythms

DebraL IrsikW.BollagC.Isales

Biology, Medicine

The FASEB Journal   1 May 2022

The data suggest that kynurenine treatment impacts renalfunction and may contribute to the development of CKD, a significant riskfactor for cardiovascular disease, even in the context of normotension.

Changes inOxygen Consumption and Metabolomic Profiles in the Kidney of Sprague‐Dawley Rat fed a High‐Salt Diet

S.ShimadaBrianR. HoffmannAndrewS. GreeneMingyuLiangR.DashA.Cowley

Medicine, Biology

The FASEB Journal  1May 2022

It is concluded that a high‐salt diet increases oxygenconsumption and alters the metabolomic profiles of the kidney.

Toward the InterdisciplinaryTheory and Research

O.Yanitsky

Creative Education  6 March 2020

The article represents some thoughts and considerationson an interdisciplinary theory and research based on the relevant scientificworks and the author’s personal and “big family” experience and…

Toward theInterdisciplinary Theory and Research

AixaHafsha  19 April 2020

The article represents some thoughts and considerationson an interdisciplinary theory and research based on the relevant scientificworks and the author’s personal and “big family” experience and… 

High Salt DietIncreases Renal Oxygen Consumption in Sprague‐Dawley Rats

S.ShimadaR.DashA.Cowley

The FASEB Journal  1May 2021

It appears that in normal SD rats, the increased tubular metabolic workassociated with a high salt diet is initially accommodated by increasedperfusion (RBF) and a gradual increase of O2 consumption while extractionremains unchanged for a two‐week period.

Chronic RenalArtery Insulin Infusion Decreases 24 hr/day Renal Blood Flow in Diabetic Rats

M.BrandsW.Bush   Medicine, Biology

The FASEB Journal  1May 2021

A chronic renal vasoconstrictor influence of insulinunder diabetic conditions is suggested, which suggests that the decrease ininsulin may contribute directly to the renal vasodilation that occurs in type 1diabetes.

M.CrostelliO.MazzaM.MarianiD.MascelloC.Iorio

International Orthopaedics 14 September 2018

Bracing is a viable treatment strategy in thoracic lumbarkyphosis and can obtain good clinical results at medium terms follow-up even ifkyPHosis deformity remains in radiographs, as even smallest devices availableare often too big.

Precise Controlof Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control ofSurface Temperature.

B.LaughlinI.BaileyS.RiceZ.BaratiLoriK. BogrenK.Drew

Therapeutic Hypothermia and Temperature…1 June 2018

An intravenous delivery protocol for CHA at 0.25mg/(kg·h) that, when coupled with conductive cooling, achievesand maintains a prescribed and consistent target Tb between 32°Cand 34°C for 24 hours.

Physiologicalhyperinsulinemia caused by acute hyperglycemia minimizes renal sodium loss bydirect action on kidneys.

DebraL IrsikM.Brands

Medicine, Biology American Journal of Physiology.Regulatory…  23 May 2018

The hypothesis that meal-induced increases in plasmainsulin are a major component of normal sodium homeostasis, and that thisoccurs by direct action of insulin on the kidney is supported.

The normalincrease in insulin after a meal may be required to prevent postprandial renalsodium and volume losses.

DebraL IrsikB.Blazer-YostA.StaruschenkoM.Brands

Medicine, Biology

American Journal of Physiology. Regulatory…   1 June 2017

It is demonstrated that the normal increase incirculating insulin in response to hyperglycemia may be required to preventexcessive renal sodium and volume losses and suggested that insulin may be a physiologicalregulator of sodium balance.